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STROMAL VASCULAR FRACTION

Human fat is a higly microvascularized organ with important metabolic, regulatory, and plastic roles. The stromal vascular fraction (SVF) derived from enzymatic digestion of  adipose tissue, corresponds to the scaffolding of  adipocytes and  contains heterogeneous cell populations such as fibroblasts, connective tissue fibers, immunomodulatory cells ( e.g., macrophages, limphocytes), mesenchymal stem cells, adipose derived stem cells, endothelial cells and pericytes. Adipose Derived Stem Cells (ASCs), are mesenchymal multipotent stem cells, localize in the stromal vascular fraction (SVF), being present in a vascular niche and they are located in capillaries supporting endothelial cells, like pericytes.